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Can Anti-Metastatic Albumin-based Superoxide Dismutase Mimetic Serve as a “Moonshot” Drug for Treatment for Brain Tumors - From Medulloblastoma to Glioblastoma?

Hsia, Carleton J. C., Messerli, Shanta M., Miskimins, W. Keith

Journal:

Cell Biochemistry and Biophysics

Année:

2019

Langue:

english

Fichier:

PDF, 305 KB

english, 2019

Cyclin-dependent kinase inhibitor P27kip1 is expressed at high levels in cells that express a myelinating phenotype

Andrew J. Friessen, W. Keith Miskimins, Robin Miskimins

Journal:

Journal of Neuroscience Research

Année:

1997

Langue:

english

Fichier:

PDF, 231 KB

english, 1997

Cyclin dependent kinase inhibitor p27Kip1 is upregulated by hypoxia via an ARNT dependent pathway

Gang Wang, Richard Reisdorph, Robert E. Clark Jr., Robin Miskimins, Ronald Lindahl, W. Keith Miskimins

Journal:

Journal of Cellular Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 269 KB

english, 2003

Involvement of multiple subcellular compartments in intracellular processing of epidermal growth factor

W. Keith Miskimins, Nobuyoshi Shimizu

Journal:

Journal of Cellular Biochemistry

Année:

1982

Langue:

english

Fichier:

PDF, 502 KB

english, 1982

Interaction of multiple factors with a GC-rich rlement within the mitogen responsive region of the human transferrin receptor gene

W. Keith Miskimins

Journal:

Journal of Cellular Biochemistry

Année:

1992

Langue:

english

Fichier:

PDF, 692 KB

english, 1992

Dual pathways for epidermal growth factor processing after receptor-mediated endocytosis

W. Keith Miskimins, Nobuyoshi Shimizu

Journal:

Journal of Cellular Physiology

Année:

1982

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1982

Uptake of epidermal growth factor into a lysosomal enzyme-deficient organelle: Correlation with cell's mitogenic response and evidence for ubiquitous existence in fibroblasts

W. Keith Miskimins, Nobuyoshi Shimizu

Journal:

Journal of Cellular Physiology

Année:

1984

Langue:

english

Fichier:

PDF, 1.09 MB

english, 1984

Partial purification of Xenopus laevis egg extract factor(s) that induce swelling in permeabilized human sperm

David B. Brown, W. Keith Miskimins, Frank H. Ruddle

Journal:

Journal of Experimental Zoology Part A Ecological Genetics and Physiology

Année:

1991

Langue:

english

Fichier:

PDF, 923 KB

english, 1991

p27Kip1 Enhances myelin basic protein gene promoter activity

Robin Miskimins, Rekha Srinivasan, Mireya Marin-Husstege, W. Keith Miskimins, Patrizia Casaccia-Bonnefil

Journal:

Journal of Neuroscience Research

Année:

2002

Langue:

english

Fichier:

PDF, 133 KB

english, 2002

Sox10 acts as a tissue-specific transcription factor enhancing activation of the myelin basic protein gene promoter by p27Kip1 and Sp1

Qiou Wei, W. Keith Miskimins, Robin Miskimins

Journal:

Journal of Neuroscience Research

Année:

2004

Langue:

english

Fichier:

PDF, 223 KB

english, 2004

Genetics of receptors for bioactive polypeptides: A variant of swiss/3T3 fibroblasts resistant to a cytotoxic insulin accumulates lysosome-like vesicles

W. Keith Miskimins, Wayne R. Ferris, Nobuyoshi Shimizu

Journal:

Journal of Cellular Biochemistry

Année:

1981

Langue:

english

Fichier:

PDF, 746 KB

english, 1981

Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes

Robert E. Clark Jr, W. Keith Miskimins, Robin Miskimins

Journal:

Journal of Neurochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 155 KB

english, 2002

The major transcription initiation site of thep27Kip1gene is conserved in human and mouse and produces a long 5'-UTR

Jennifer Coleman, Michelle Hawkinson, Robin Miskimins, W Keith Miskimins

Journal:

BMC Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 614 KB

english, 2001

Expression of constitutively active 4EBP-1 enhances p27Kip1expression and inhibits proliferation of MCF7 breast cancer cells

Hong Jiang, Jennifer Coleman, Robin Miskimins, W Keith Miskimins

Journal:

Cancer Cell International

Année:

2003

Langue:

english

Fichier:

PDF, 918 KB

english, 2003

Galectin-4 is involved in p27-mediated activation of the myelin basic protein promoter

Qiou Wei, Tamar Eviatar-Ribak, W. Keith Miskimins, Robin Miskimins

Journal:

Journal of Neurochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 649 KB

english, 2007

The cyclin-dependent kinase inhibitor p27Kip1 is localized to the cytosol in Swiss/3T3 cells

Wang, Gang, Miskimins, Robin, Miskimins, W Keith

Journal:

Oncogene

Année:

1999

Langue:

english

Fichier:

PDF, 448 KB

english, 1999

HPV+ cancer cell lactate production attenuates immune response during treatment: lactate production inhibition leads to improved long-term cures

Cathy Zhuang, Dan Vermeer Yuh-Seog Jung, Allison Haugrud, John H Lee, Keith Miskimins

Journal:

Infectious Agents and Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 81 KB

english, 2012

The Same Xenobiotic Response Element Is Required for Constitutive and Inducible Expression of the Mammalian Aldehyde Dehydrogenase-3 Gene

Josette S. Boesch, Robin Miskimins, W.Keith Miskimins, Ronald Lindahl

Journal:

Archives of Biochemistry and Biophysics

Année:

1999

Langue:

english

Fichier:

PDF, 264 KB

english, 1999

Mimosine Arrests Cells in G1 by Enhancing the Levels of p27Kip1

Gang Wang, Robin Miskimins, W.Keith Miskimins

Journal:

Experimental Cell Research

Année:

2000

Langue:

english

Fichier:

PDF, 155 KB

english, 2000

ATF-1 Is Activated in Response to UV Irradiation in B16 Melanoma Cells

Billie A. Moore, Robin Miskimins, W.Keith Miskimins

Journal:

Molecular Cell Biology Research Communications

Année:

1999

Langue:

english

Fichier:

PDF, 114 KB

english, 1999

A supercoil-dependent structural alteration within the regulatory region of the human transferrin receptor gene

Qian Ouyang, W.Keith Miskimins

Journal:

Biochemical and Biophysical Research Communications

Année:

1992

Langue:

english

Fichier:

PDF, 1.17 MB

english, 1992

Epidermal growth factor-induced topoisomerase(s): Intracellular translocation and relation to DNA synthesis

Robin Miskimins, W.Keith Miskimins, Harris Bernstein, Nobuyoshi Shimizu

Journal:

Experimental Cell Research

Année:

1983

Langue:

english

Fichier:

PDF, 2.25 MB

english, 1983

Analysis of cis-acting promoter elements using microinjected synthetic oligonucleotides

W.Keith Miskimins, David B. Brown

Journal:

Experimental Cell Research

Année:

1990

Langue:

english

Fichier:

PDF, 4.23 MB

english, 1990

A cytotoxic epidermal growth factor cross-linked to diphtheria toxin A-fragment

Nobuyoshi Shimizu, W.Keith Miskimins, Yoshiko Shimizu

Journal:

FEBS Letters

Année:

1980

Langue:

english

Fichier:

PDF, 781 KB

english, 1980

Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site

Yuhuan Zheng, W. Keith Miskimins

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2011

Langue:

english

Fichier:

PDF, 996 KB

english, 2011

Cloning and characterization of the rat myelin basic protein gene promoter

Qiou Wei, W.Keith Miskimins, Robin Miskimins

Journal:

Gene

Année:

2003

Langue:

english

Fichier:

PDF, 948 KB

english, 2003

A role for an AP-1-like site in the expression of the myelin basic protein gene during differentiation

Robin Miskimins, W.Keith Miskimins

Journal:

International Journal of Developmental Neuroscience

Année:

2001

Langue:

english

Fichier:

PDF, 217 KB

english, 2001

Cyclic AMP inducibility of the myelin basic protein gene promoter requires the NF1 site

Robert E. Clark Jr., W.Keith Miskimins, Robin Miskimins

Journal:

International Journal of Developmental Neuroscience

Année:

2002

Langue:

english

Fichier:

PDF, 188 KB

english, 2002

Involvement of map kinase in the cyclic amp induction of myelin basic protein gene expression

Robert Clark, Mitchell Stewart, W.Keith Miskimins

Journal:

International Journal of Developmental Neuroscience

Année:

1998

Langue:

english

Fichier:

PDF, 240 KB

english, 1998

Synthesis of a cytotoxic insulin cross-linked to diphtheria toxin fragment a capable of recognizing insulin receptors

W.Keith Miskimins, Nobuyoshi Shimizu

Journal:

Biochemical and Biophysical Research Communications

Année:

1979

Langue:

english

Fichier:

PDF, 3.33 MB

english, 1979

Metformin and phenethyl isothiocyanate combined treatmentin vitrois cytotoxic to ovarian cancer cultures

Daniel K Chan, W Keith Miskimins

Journal:

Journal of Ovarian Research

Année:

2012

Langue:

english

Fichier:

PDF, 472 KB

english, 2012

Promise of rapalogues versus mTOR kinase inhibitors in subset specific breast cancer: Old targets new hope

De, Pradip, Miskimins, Keith, Dey, Nandini, Leyland-Jones, Brian

Journal:

Cancer Treatment Reviews

Année:

2013

Langue:

english

Fichier:

PDF, 718 KB

english, 2013

Improved Clearance during Treatment of HPV-Positive Head and Neck Cancer through mTOR Inhibition

Coppock, Joseph D., Wieking, Bryant G., Molinolo, Alfredo A., Gutkind, J. Silvio, Miskimins, W. Keith, Lee, John H.

Journal:

Neoplasia

Année:

2013

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2013

[Part 2: Biological Sciences] || Genetics of Cell Surface Receptors for Bioactive Polypeptides: Variants of Swiss/3T3 Fibroblasts Resistant to a Cytotoxic Chimeric Insulin

W. Keith Miskimins and Nobuyoshi Shimizu

Journal:

Proceedings of the National Academy of Sciences

Année:

1981

Langue:

english

Fichier:

PDF, 1.61 MB

english, 1981

Use of a Protein-Blotting Procedure and a Specific DNA Probe to Identify Nuclear Proteins That Recognize the Promoter Region of the Transferrin Receptor Gene

W. Keith Miskimins, Michael P. Roberts, Alan McClelland and Frank H. Ruddle

Journal:

Proceedings of the National Academy of Sciences

Année:

1985

Langue:

english

Fichier:

PDF, 1.32 MB

english, 1985

Part 1 || Cell Proliferation and Expression of the Transferrin Receptor Gene: Promoter Sequence Homologies and Protein Interactions

W. Keith Miskimins, Alan McClelland, Michael P. Roberts and Frank H. Ruddle

Journal:

The Journal of Cell Biology

Année:

1986

Langue:

english

Fichier:

PDF, 1.95 MB

english, 1986

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

Haugrud, Allison B., Zhuang, Yongxian, Coppock, Joseph D., Miskimins, W. Keith

Journal:

Breast Cancer Research and Treatment

Année:

2014

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2014

CUG-binding protein represses translation of p27Kip1 mRNA through its internal ribosomal entry site

Zheng, Yuhuan, Miskimins, W. Keith

Journal:

RNA Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2011

Deregulation of IRES-mediated p53 translation in cancer cells with defective p53 response to DNA damage

Halaby, Marie-Jo, Harris, Benjamin R. E., Miskimins, W. Keith, Cleary, Margot P., Yang, Da-Qing

Journal:

Molecular and Cellular Biology

Année:

2015

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2015

Structure and activity of the internal ribosome entry site within the human p27Kip1 5’-untranslated region

Coleman, Jennifer, Miskimins, W. Keith

Journal:

RNA Biology

Année:

2009

Langue:

english

Fichier:

PDF, 426 KB

english, 2009

Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs

Yang, Xiaoyu, Xu, Yi, Brooks, Amanda, Guo, Bin, Miskimins, Keith W., Qian, Steven Y.

Journal:

Free Radical Biology and Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2016

Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo

Zhuang, Yongxian, Chan, Daniel K., Haugrud, Allison B., Miskimins, W. Keith, Shridhar, Viji

Journal:

PLoS ONE

Année:

2014

Langue:

english

Fichier:

PDF, 2.77 MB

english, 2014

Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells

Yang, Xiaoyu, Xu, Yi, Wang, Tao, Shu, Dan, Guo, Peixuan, Miskimins, Keith, Qian, Steven Y.

Journal:

Redox Biology

Année:

2017

Langue:

english

Fichier:

PDF, 2.48 MB

english, 2017

Knocking Down Delta-5 Desaturase and Exploiting High Expression Level of COX-2 to Inhibit Cancer Migration and Invasion

Yang, Xiaoyu, Xu, Yi, Miskimins, Keith W, Qian, Steven Y

Journal:

Free Radical Biology and Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 256 KB

english, 2016

Suppressing Colon Cancer Growth in Xenograft Tumors via Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Expression Levels in Cancer

Xu, Yi, Yang, Xiaoyu, Gao, Di, Miskimins, Keith, Qian, Steven

Journal:

Free Radical Biology and Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 256 KB

english, 2016

Erratum to “Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells” [Redox Biol. 11 (2017) 653–662]

Yang, Xiaoyu, Xu, Yi, Wang, Tao, Shu, Dan, Guo, Peixuan, Miskimins, Keith, Qian, Steven Y.

Journal:

Redox Biology

Année:

2017

Langue:

english

Fichier:

PDF, 275 KB

english, 2017

DDIS-17. POLYNITROXYL ALBUMIN INHIBITS BRAIN TUMORIGENIC CASCADE THROUGH A REACTIVE OXYGEN SPECIES MECHANISM ACROSS THE BLOOD BRAIN BARRIER

Grausam, Katie, Lanier, Ross, Schaefer, Amanda, Ma, Li, Soltys, Bohdan, Hsia, Carleton, Miskimins, Keith, Zhao, Haotian

Journal:

Neuro-Oncology

Année:

2017

Langue:

english

Fichier:

PDF, 58 KB

english, 2017

Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism

Xu, Yi, Yang, Xiaoyu, Wang, Tao, Yang, Liu, He, Yu-Ying, Miskimins, Keith, Qian, Steven Y.

Journal:

BMC Cancer

Année:

2018

Langue:

english

Fichier:

PDF, 7.55 MB

english, 2018

Synergistic Anti-Cancer Effect of Phenformin and Oxamate

Miskimins, W. Keith, Ahn, Hyun Joo, Kim, Ji Yeon, Ryu, Sun, Jung, Yuh-Seog, Choi, Joon Young, Moreno-Sanchez, Rafael

Journal:

PLoS ONE

Année:

2014

Langue:

english

Fichier:

PDF, 4.75 MB

english, 2014

Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage

Halaby, Marie-Jo, Li, Yan, Harris, Benjamin R., Jiang, Shuxia, Miskimins, W. Keith, Cleary, Margot P., Yang, Da-Qing

Journal:

BioMed Research International

Année:

2015

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2015